November 6th, 2013

thCA4CKW23I went to the lab yesterday morning to have my annual fasting bloodwork drawn.  Two large tubes of blood were drawn uneventfully (I didn’t scream or cry!) for just a handful of basic tests that will end up costing me a few hundred dollars.  Stanford drop-out and entrepreneur Elizabeth Holmes is about to change all that.  Joseph Rago explains the journey my blood sample currently takes:

“The art of phlebotomy originated with bloodletting in 1400 B.C. and the modern clinical lab emerged in the 1960s—and it has not fundamentally evolved since then,” she says. The billions of tests generally follow the same ritual: In a hospital or clinic, “you go in, sit down, they put a tourniquet on your arm, stick you with a needle, take these tubes and tubes of blood,” as Ms. Holmes describes it.

The specimens are then transported, via a courier or hospital pneumatic tube, to a centralized lab, where they are manually removed from the tubes with a pipette and mixed with a chemical reagent or sent through instruments like a centrifuge or mass spectrometer. After days or weeks of waiting, your doctor finally gets the results.

 

Holmes’ company (Theranos) has created a revolutionary process in which only a drop of blood from a fingerstick is needed to run multiple tests, simple and complicated.  Rago describes the procedure, which should get the attention of every parent who has had to pin down their child in order to get a blood sample:

The secret that hundreds of employees are now refining involves devices that automate and miniaturize more than 1,000 laboratory tests, from routine blood work to advanced genetic analyses. Theranos’s processes are faster, cheaper and more accurate than the conventional methods and require only microscopic blood volumes, not vial after vial of the stuff. The experience will be revelatory to anyone familiar with current practices, which often seem like medicine by                                     Bram Stoker.

A Theranos technician first increases blood flow to your hand by applying a wrap similar to one of those skiing pocket warmers, then uses a fingerstick to draw a few droplets of blood from the capillaries at the end of your hand. The blood wicks into a tube in a cartridge that Ms. Holmes calls a “nanotainer,” which holds microliters of a sample, or about the amount of a raindrop. The nanotainer is then run through the analyzers in a Theranos laboratory.

 

If it becomes so simple (and inexpensive) to take a blood sample, and the results become available to the ordering physician within a matter of hours instead of days or weeks, won’t that lead doctors to order more tests (or patients to request them)?  Pediatrician William G. Wilkoff thinks so:

Hmmm. Maybe it’s time for us to pause and take a breath. Listen. Is that creaking sound I hear the rusty hinges of Pandora’s box opening? It’s hard to argue with cutting health care costs, improving accuracy, and shortening the anxiety-provoking wait that many patients endure waiting for their lab results to reach them. But, this “breakthrough” sounds like it has the potential for creating a tsunami of TMI (too much information).

Physicians already order too many lab tests, in many cases a defensive strategy. Often physicians don’t know what to do with borderline results. The temptation is to retest, and soon the doctor finds herself in unfamiliar waters chasing an elusive school of red herring. The Theranos technology promises to make ordering blood tests cheaper and easier, and, predictably, physicians will respond by ordering more of them.

 

Wilkoff is probably right.  Still, Holmes is banking on her product to drive down the costs of laboratory services everywhere, all while administering less pain to patients (especially children).  It will still be up to well-trained physicians to continue to use evidence-based medical guidelines and common sense to decide when — or when not — to order tests.  I think doctors can handle that.

 

(Yahoo! Images)

 

 

 

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One Response to One Small Ow-wee

  1. Deborah Rotenstein,MD

    This is GREAT Stuff! Hope it will come to hormone assays soon!

  • MEET THE EDITOR

    Ned Ketyer, M.D.

    Ned Ketyer, M.D.

    Dr. Ketyer has special interests in developmental pediatrics and preventative medicine, specifically how nutrition and the environment affect health. He earned his bachelor’s degree from the University of Vermont and his medical degree from Northwestern University Medical School. He completed his residency at Children’s Hospital of Pittsburgh.

    As one of the founding physicians of Pediatric Alliance, PC, Dr. Ketyer served as its president from 1997-2004. He has been practicing general pediatrics at Pediatric Alliance since 1990. Dr. Ketyer and his wife have three boys and live in Pittsburgh's South Hills. 



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